100000 - Document - DOCUMENT AND ENTITY INFORMATION
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100010 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS
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100020 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
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100030 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS
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100040 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY
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100050 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Parenthetical)
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100060 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
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995455 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
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995465 - Disclosure - REVENUE RECOGNITON
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995475 - Disclosure - INVENTORY
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995485 - Disclosure - FAIR VALUE MEASUREMENTS
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995495 - Disclosure - ACCRUED LIABILITIES
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995505 - Disclosure - DEBT
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995515 - Disclosure - CONTINGENCIES AND UNCERTAINTIES
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995525 - Disclosure - STOCKHOLDERS' EQUITY
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995535 - Disclosure - SUBSEQUENT EVENTS
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995545 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Policies)
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995555 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Tables)
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995565 - Disclosure - REVENUE RECOGNITON (Tables)
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995575 - Disclosure - INVENTORY (Tables)
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995585 - Disclosure - FAIR VALUE MEASUREMENTS (Tables)
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995595 - Disclosure - ACCRUED LIABILITIES (Tables)
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995605 - Disclosure - DEBT (Tables)
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995615 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - NET LOSS PER SHARE (Details)
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995625 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - ANTI-DILUTIVE SHARES (Details)
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995635 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - USEFUL LIVES OF ASSETS (Details)
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995645 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - STOCK BASED COMPENSATION (Details)
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995655 - Disclosure - SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES - STOCK OPTIONS AND EMPLOYEE STOCK PURCHASE PLAN (Details)
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995665 - Disclosure - REVENUE RECOGNITON - Schedule of Reconciliation of Gross Product Sales to Net Product Sales (Details)
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995675 - Disclosure - REVENUE RECOGNITON - Schedule of Gross-to-Net Sales Adjustments (Parenthetical) (Details)
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995685 - Disclosure - INVENTORY - Schedule of Inventory (Details)
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995695 - Disclosure - FAIR VALUE MEASUREMENTS - SECURITY TYPE (Details)
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995705 - Disclosure - FAIR VALUE MEASUREMENTS - SECURITIES WITH UNREALIZED LOSSES (Details)
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995715 - Disclosure - FAIR VALUE MEASUREMENTS - Additional Information (Details)
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995725 - Disclosure - FAIR VALUE MEASUREMENTS - RECURRING BASIS (Details)
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995735 - Disclosure - FAIR VALUE MEASUREMENTS - EQUITY INVESTMENT (Details)
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995745 - Disclosure - ACCRUED LIABILITIES (Details)
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995755 - Disclosure - DEBT - Additional Information (Details)
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995765 - Disclosure - DEBT - Future Minimum Payments Under Loan Agreement (Details)
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995775 - Disclosure - CONTINGENCIES AND UNCERTAINTIES - Severance Plan (Details)
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995785 - Disclosure - STOCKHOLDERS' EQUITY - REGISTERED OFFERING (Details)
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995795 - Disclosure - STOCKHOLDERS' EQUITY - WARRANT EXERCISES (Details)
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995805 - Disclosure - STOCKHOLDERS' EQUITY - 2023 At Market Issuance Sales Agreement (Details)
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995815 - Disclosure - STOCKHOLDERS' EQUITY - EMPLOYEE STOCK PURCHASE PLAN (Details)
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995825 - Disclosure - STOCKHOLDERS' EQUITY - 2018 EQUITY INCENTIVE PLAN (Details)
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995835 - Disclosure - STOCKHOLDERS' EQUITY - 2018 INDUCEMENT AWARD PLAN (Details)
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995845 - Disclosure - SUBSEQUENT EVENTS - Additional Information (Details)
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Statement [Line Items]
Statement [Line Items]
Debt Instrument
Debt Instrument [Axis]
Increase (Decrease) in Accounts Receivable
Accounts receivable, net
Scenario One
Scenario One [Member]
Scenario one.
Plan Name [Domain]
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Debt covenant percentage of product revenue against forecast
Minimum cash balance requirement to be met as a percentage of six-month product revenue against forecast
Minimum percentage of six-month product revenue forecast to satisfy minimum cash balance debt covenant.
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value, Recurring and Nonrecurring [Table]
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Revenues:
Revenues [Abstract]
Public Offering [Table]
Public Offering [Table]
Public offering.
BioPharma Credit PLC
BioPharma Credit PLC [Member]
BioPharma credit PLC.
Government-sponsored enterprise securities
US Government-sponsored Enterprises Debt Securities [Member]
Government-sponsored enterprise securities (due in less than one year)
Government Sponsored Enterprise Securities Due In Less Than One Year [Member]
Government sponsored enterprise securities due in less than one year.
Revenue interest payments description
Revenue, Performance Obligation, Description of Payment Terms
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Axis]
Anil Kapur
Anil Kapur [Member]
Anil Kapur.
At Market Issuance Sales Agreements [Line Items]
At Market Issuance Sales Agreements [Line Items]
At Market Issuance Sales Agreements.
Level 2
Fair Value, Inputs, Level 2 [Member]
Stock-Based Compensation
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share-Based Payment Arrangement, Amount Capitalized
Stock-based compensation capitalized
Total gross to net adjustments.
Total Gross To Net Adjustments [Member]
Total gross-to-net adjustments
Percentage of loan amount outstanding to be held as minimum cash balance under debt covenant.
Debt covenant minimum cash balance percentage of loan amount
Minimum cash balance as a percentage of loan amount outstanding
Long-term Debt, Current Maturities, Total
Less: current portion of debt
Long-Term Debt, Current Maturities
Less: current portion of debt
Commercial paper (due in less than one year)
Commercial Paper Due In Less Than One Year [Member]
Represents information pertaining to unsecured promissory note (generally negotiable) that provides institutions with short-term funds ), due in less than one year.
CONTINGENCIES AND UNCERTAINTIES
Commitments and Contingencies Disclosure [Text Block]
Municipal securities (due in one to two years)
Municipal Securities Due In One To Two Years [Member]
Municipal securities due in one to two years member.
Product and Service [Axis]
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments, Noncash Items, to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Fair value of equity investment
Investment Owned, Fair Value
Investment Owned, at Fair Value, Beginning Balance
Investment Owned, at Fair Value, Ending Balance
2020 Public Offering of Common Stock and Warrants.
2020 Public Offering of Common Stock and Warrants
Two Thousand Twenty Public Offering Of Common Stock And Warrants [Member]
Option two min cash debt covenant.
Option Two Min Cash Debt Covenant [Member]
Option Two Min Cash Debt Covenant [Member]
Title and Position [Axis]
Revenue from Contract with Customer [Text Block]
REVENUE RECOGNITON
Sale of Stock
Sale of Stock [Domain]
Principal amount outstanding under term loan
Long-Term Debt, Gross
Total
Debt covenant minimum cash balance upon licensing transaction
Debt Covenant Min Cash Upon Licensing Transaction
Minimum cash covenant required upon certain licensing transactions being executed.
Schedule of cash equivalents and marketable securities with unrealized losses
Debt Securities, Available-for-Sale, Unrealized Loss Position, Fair Value [Table Text Block]
U.S. Treasury securities (due in one to two years)
U S Treasury Securities Due In One To Two Years [Member]
US Treasury securities due in one to two years member.
U.S. Treasury securities - due in 1 to 2 years
Inventory, Policy [Policy Text Block]
Inventory
Entity Central Index Key
Entity Central Index Key
Schedule Of Available For Sale Securities [Line Items]
Debt Securities, Available-for-Sale [Line Items]
Tranche B
Tranche B [Member]
Tranche B [Member]
Tranche B [Member]
Amortized Cost
Cash Equivalents, at Carrying Value
Changes in assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
At The Market Offering
At The Market Offering [Member]
At The Market Offering Member.
Risk-free interest rate range, minimum (as a percent)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses, interest receivable and other assets
Municipal securities (due in less than one year)
Municipal Securities Due In Less Than One Year [Member]
Municipal securities due in less than one year.
Income Statement [Abstract]
Public Offering [Line Items]
Public Offering [Line Items]
Public offering.
Foreign currency translation adjustment
Adjustment To Accumulated Other Comprehensive Gain Loss Foreign Currency Translation Adjustment
Adjustment to accumulated other comprehensive gain loss foreign currency translation adjustment.
Entity Address, State or Province
Entity Address, State or Province
SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
Organization, Consolidation and Presentation of Financial Statements Disclosure and Significant Accounting Policies [Text Block]
Stock Issued During Period, Value, Employee Stock Purchase Plan
Employee stock purchases
Class of Warrant or Right [Table]
Issuance Of Common Stock In Connection With Warrant Exercise Shares
Number of new shares issued during the period in connection with exercise of warrants.
Issuances of common stock in connection with exercise of warrants (in shares)
Cost method investments ownership percentage
Cost Method Investment Ownership Percentage
Cost method investment ownership percentage.
Total - Estimated Fair Value
Debt Securities, Available-for-Sale, Unrealized Loss Position
Net product revenue period.
Net Product Revenue Period
Net product revenue period
CRO and clinical trial costs
Accrued Clinical Research Organizations And Clinical Trial Costs Current
Carrying value as of the balance sheet date of obligations incurred through that date and payable for clinical related costs. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Cover [Abstract]
Subsequent Event [Line Items]
Earnings Per Share, Basic, Total
Earnings Per Share, Basic
Basic net loss per share
Debt Issuance Costs, Gross
Debt issuance costs
Gross Unrealized Gains
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Operating expenses:
Operating Expenses [Abstract]
Tranche one.
Tranche One [Member]
John A. Scarlett, M.D.
John A. Scarlett, M.D. [Member]
John A. Scarlett, M.D.
Debt Instrument, Unused Borrowing Capacity, Amount
Available remaining loan committed principal
Share-Based Payment Arrangement, Expense
Total stock-based compensation expense
Issuance of common stock in connection with public offering (in shares)
Share Of Common Stock Issued During Period Shares New Issues Public Offering
Number of new shares of common stock issued during the period in connection with public offering.
Long-term Debt, Total
Carrying value of term loan, net
Long-Term Debt
Third Amendment [Member]
Third Amendment [Member]
Third amendment.
Retained Earnings (Accumulated Deficit), Ending Balance
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Total
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Plan Name [Axis]
Tranche A
Tranche A [Member]
Tranche A [Member]
Tranche A [Member]
Current assets:
Assets, Current [Abstract]
Common Stock, Capital Shares Reserved for Future Issuance
Common stock, shares reserved for future issuance (in shares)
Line of credit, maturity period
Line of Credit Facility, Expiration Period
Investment Type
Investment Type [Axis]
Cash flows from operations
Net cash used in operating activities
Net Cash Provided by (Used in) Operating Activities
Product and Service [Domain]
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated Other Comprehensive Income (Loss), Net of Tax
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Property, Plant and Equipment, Net, Ending Balance
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net, Total
Property and equipment, net
Property, Plant and Equipment, Net
Cash flows from operating activities:
Net Cash Provided by (Used in) Operating Activities [Abstract]
Recurring basis
Fair Value, Recurring [Member]
2024 Pre-funded Warrant
Two Thousand Twenty Four Pre Funded Warrant [Member]
Two thousand twenty four pre-funded warrant.
Corporate notes
Corporate Note Securities [Member]
Schedule of financial instruments measured at fair value on recurring basis
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Vesting [Axis]
Stock Options
Net unrealized gain/ (loss) on marketable securities
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Other comprehensive income (loss)
Accounts Receivable [Policy Text Block]
Accounts Receivable
Statement of Cash Flows [Abstract]
Counterparty Name [Axis]
Floor rate
Debt Instrument Floor Rate
Debt instrument floor rate.
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Warrant to purchase common stock, shares
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Selling, General and Administrative Expenses [Member]
Selling, general and administrative
Equity Components
Equity Components [Axis]
Schedule of gross to net sales adjustments.
Schedule Of Gross To Net Sales Adjustments [Table Text Block]
Schedule of Reconciliation of Gross Product Sales to Net Product Sales
Entity Address, Address Line One
Entity Address, Address Line One
Dollar prepayment charge 36 months after effective date
Charge for prepayment occurring 36 months after effective date
Prepayment charge assessed upon debt prepayment occurring 36 months after June 30, 2022 under second amendment.
Employee-related Liabilities, Current, Total
Accrued compensation and benefits
Employee-related Liabilities, Current
Government-sponsored enterprise securities (due in less than one year)
U S Government Sponsored Enterprises Debt Securities Due In Less Than One Year [Member]
Represents information pertaining to debentures, bonds and other debt securities issued by US government sponsored entities (GSEs), for example, but not limited to, Federal Home Loan Mortgage Corporation (FHLMC or Freddie Mac), Federal National Mortgage Association (FNMA or Fannie Mae), and the Federal Home Loan Bank (FHLB). Excludes debt issued by the Government National Mortgage Association (GNMA or Ginnie Mae, due in less than one year.
Subsequent Event Type [Axis]
Maximum borrowing capacity under term loan
Line of Credit Facility, Maximum Borrowing Capacity
Unamortized debt discount and issuance costs
Unamortized Debt Issuance Expense
Less: unamortized debt discounts and issuance costs
Two thousand and eighteen inducement award plan.
Two Thousand And Eighteen Inducement Award Plan [Member]
2018 Inducement Award Plan
Amendment Flag
Amendment Flag
Noncurrent operating lease liabilities
Operating Lease, Liability, Noncurrent
2022 Pre-Funded Warrant
Two Thousand Twenty Two Pre Funded Warrant [Member]
2022 pre-funded warrant.
Debt Instrument, Name
Debt Instrument, Name [Domain]
Additional Paid in Capital, Common Stock, Ending Balance
Additional Paid in Capital, Common Stock, Beginning Balance
Additional paid-in capital
Additional Paid in Capital, Common Stock
Noncurrent marketable securities
Debt Securities, Available-for-Sale, Noncurrent
Combined public offering price per share of pre-funded warrant and accompanying stock purchase warrant
Sale of Stock, Price Per Share
Public offering price per share
Net loss
Net loss
Operating Costs and Expenses, Total
Operating Costs and Expenses
Cost of goods sold
Variable Rate [Domain]
Research and development
Research and Development Expense [Member]
Hercules and Silicon Valley Bank [Member]
Hercules And Silicon Valley Bank [Member]
Hercules and Silicon Valley Bank. member.
Equity Component
Equity Component [Domain]
Start date to borrow under a tranche for a debt instrument
Borrowing Available Start Date
First date to available to drawdown any amount under a tranche.
Statistical Measurement
Statistical Measurement [Domain]
Scenario Three
Scenario Three [Member]
Scenario three.
Other Nonoperating Income (Expense), Total
Other income and (expense), net
Other Nonoperating Income (Expense)
Disaggregation of Revenue [Table]
Aggregate offering price of common stock
Common Stock Aggregate Offering Price
Represents the aggregate offering price for which the entity may elect to issue and sell shares of its common stock under the sales agreement.
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Debt Instrument, Variable Interest Rate, Type [Extensible Enumeration]
Debt discount amount
Debt Instrument, Unamortized Discount, Total
Debt Instrument, Unamortized Discount
Debt discount under second amendment
Less: unamortized debt discounts and issuance costs
Payables and Accruals [Abstract]
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Employee stock purchases (in shares)
Less: unaccrued end of term charge
Debt Instrument Unaccrued End Of Term Charge
Debt instrument unaccrued end of term charge.
Royalties Payable
Accrued Royalties
Prepaid and other current assets
Prepaid Expense and Other Assets, Current
Risk-free interest rate range, maximum (as a percent)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum
Pharmakon Loan Agreement
Pharmakon Loan Agreement [Member]
Pharmakon loan agreement.
Gross Unrealized Losses
Cash And Cash Equivalents Unrealized Losses
Represents the gross unrealized losses for cash and cash equivalents.
3rd Anniversary But, Prior To 4th Anniversary Of Funding Date
Prepaid On Or After Third Anniversary But Prior To Fourth Anniversary Of Funding Date [Member]
Prepaid on or after third anniversary but prior to fourth anniversary of funding date.
Severance plans
Number Of Severance Plan
Number of severance plan.
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Class of Stock [Domain]
Debt instrument cash balance percentage.
Debt Instrument Cash Balance Percentage
Debt instrument minimum cash balance percentage.
Comprehensive loss
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Balances (in shares)
Balances (in shares)
Common Stock, Shares, Outstanding
Proceeds from maturities of marketable securities
Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-Sale
Municipal securities
Municipal Bonds [Member]
At Market Issuance Sales Agreements [Table]
At Market Issuance Sales Agreements [Table]
At Market Issuance Sales Agreements.
Antidilutive Securities
Antidilutive Securities [Axis]
Proceeds from Issuance or Sale of Equity
Proceeds from Issuance or Sale of Equity, Total
Net cash proceeds from public offering after deducting underwriting discount and other offering expenses
Entity Interactive Data Current
Entity Interactive Data Current
Product [Member]
Product Revenue, Net
Market capitalization amount.
Market Capitalization Amount
Market capitalization amount
Document Quarterly Report
Document Quarterly Report
Statistical Measurement
Statistical Measurement [Axis]
Debt Instrument, Payment Terms
Description of term loan payment terms
Total
Assets, Fair Value Disclosure
Assets, Fair Value Disclosure, Total
Revenues before adjustments.
Revenues Before Adjustments [Member]
Revenues Before Adjustments
Commercial paper
Commercial Paper [Member]
Less: amount representing interest
Interest Payable
Minimum market capitalization required for this option to be available to meet the minimum cash balance debt covenant.
Market cap minimum to use option two
Minimum market capitalization requirement for option
Maximum commission rate (as a percent)
Maximum Commission Rate
Represents the percentage of maximum commission rate, based on gross proceeds of sale price per share of common stock sold through sales agent under the sales agreement.
Loss Contingency, Nature [Domain]
Recorded Unconditional Purchase Obligation, Total
Recorded Unconditional Purchase Obligation
Noncancelable commercial purchase commitments
Research and Development Expenses
Research and Development Expense, Policy [Policy Text Block]
Income Statement Location
Statement of Income Location, Balance [Axis]
Number of shares owned
Investment Owned, Balance, Shares
Total assets
Assets
Expected term
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Stock purchase warrants.
Stock Purchase Warrants [Member]
Stock Purchase Warrants
Debt Instrument [Table]
Schedule of Long-Term Debt Instruments [Table]
Issuance Of Common Stock In Connection With Warrant Exercise Value
Equity impact of the value of stock issued in connection with exercise of warrants during the period.
Issuances of common stock in connection with exercise of warrants
Increase (decrease) in fair value of equity investment
Increase (Decrease) in Equity Securities, FV-NI
Recent Accounting Pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Entity Address, City or Town
Entity Address, City or Town
Accumulated Other Comprehensive Gain (Loss)
AOCI Attributable to Parent [Member]
Minimum amount of prepayment allowed under debt instrument
Debt Instrument Minimum Prepayment Amount
Minimum amount allowed to be prepaid under debt instrument.
Schedule of Maturities of Long-Term Debt [Table Text Block]
Future Minimum Payments Under Loan Agreement
2024 Underwritten Public Offering
Two Thousand Twenty Four Underwritten Public Offering [Member]
Two thousand twenty four underwritten public offering.
STOCKHOLDERS' EQUITY
Shareholders' Equity and Share-Based Payments [Text Block]
Principle amount
Debt Instrument, Face Amount
Expiration date to borrow under a tranche for a debt instrument
Expiry Date Of Tranche
Last date to drawdown any amounts under a tranche.
Period within which employee is terminated by entity without cause following a change of control
Loss Contingency Triggering Event Employee Termination Without Cause Following Change Of Control Period
Represents the number of months following a change in control when an employee is terminated without cause to be classified as a triggering event for severance payments.
Shares Issued, Shares, Share-based Payment Arrangement, after Forfeiture, Total
Shares Issued, Shares, Share-Based Payment Arrangement, after Forfeiture
Issuance of common stock under equity plans (in shares)
Nontrade Receivables, Current, Total
Interest and other receivables
Nontrade Receivables, Current
FAIR VALUE MEASUREMENTS
Fair Value Disclosures [Abstract]
Severance Plan
Severance Plan [Line Items]
Severance plan.
Term Loans
Term Loans [Member]
Term loans.
Equity Securities, FV-NI, Unrealized Gain (Loss), Total
Change in fair value of equity investment
Equity Securities, FV-NI, Unrealized Gain (Loss)
Upfront payment received
Upfront Payment Received
Upfront payment received.
Minimum percentage of net product revenues maintenance period.
Minimum percentage of net product revenues maintenance period
Minimum percentage of net product revenues maintenance period
Current liabilities:
Liabilities, Current [Abstract]
Stock-based compensation for services by non-employees
Issuance of Stock and Warrants for Services or Claims
U.S. Treasury securities
US Treasury Notes Securities [Member]
Document Type
Document Type
Title of 12(b) Security
Title of 12(b) Security
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Total
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Debt instruments facility costs.
Debt Instruments Facility Costs
Debt instrument, facility charge
Statement of Stockholders' Equity [Abstract]
Line of credit facility achievement period.
Line of Credit Facility Achievement Period
Line of credit facility achievement period
Percentage of commitment amount to fund loan
Percentage Of Commitment Amount To Fund Loan
Percentage of commitment amount to fund loan.
Document Fiscal Period Focus
Document Fiscal Period Focus
Noncurrent portion of debt
Noncurrent debt
Long-Term Debt, Excluding Current Maturities
Asset Class
Asset Class [Domain]
Principles of Consolidation
Consolidation, Policy [Policy Text Block]
Increase (Decrease) in Operating Liabilities, Total
Current and noncurrent liabilities
Increase (Decrease) in Operating Liabilities
Subsequent Event Type [Domain]
Leases
Lessee, Leases [Policy Text Block]
Schedule of assumptions used to estimate the fair value of service-based stock options granted
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
2020 Pre-Funded Warrant
Two Thousand Twenty Pre Funded Warrants [Member]
2020 Pre-funded warrants.
Prepayment charge (as a percentage)
Percentage Of Prepayment Charge
Percentage of prepayment amount to be paid upon prepayment under debt instrument.
Underwritten Public Offering
Underwritten Public Offering [Member]
Underwritten Public Offering [Member]
Two thousand twenty two public offering of common stock and warrants.
Two thousand twenty two public offering of common stock and warrants [Member]
2022 Public Offering of Common Stock and Warrants
12 Months or Longer - Estimated Fair Value
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer
Warrant exercise price
Class of Warrant or Right, Exercise Price of Warrants or Rights
Financial Instruments
Financial Instruments [Domain]
Gain (loss) related to foreign currency translation
Unrealized Gain (Loss), Foreign Currency Transaction, before Tax
Cost method investments cost basis
Cost Method Investments Cost Basis
Cost method investments cost basis.
Class of Warrant or Right [Line Items]
Sale of Stock
Sale of Stock [Axis]
Cash flows from investing activities:
Net Cash Provided by (Used in) Investing Activities [Abstract]
Investments
Investments [Domain]
Geron corporation.
Geron Corporation [Member]
Geron [Member]
Government-sponsored enterprise securities (due in one to two years)
Government Sponsored Enterprise Securities Due In One To Two Years [Member]
Debentures, bonds and other debt securities issued by US government sponsored entities (GSEs), for example, but not limited to, Federal Home Loan Mortgage Corporation (FHLMC or Freddie Mac), Federal National Mortgage Association (FNMA or Fannie Mae), and the Federal Home Loan Bank (FHLB). Excludes debt issued by the Government National Mortgage Association (GNMA or Ginnie Mae) due in 1 to 2 years.
Revenue from Contract with Customer, Excluding Assessed Tax, Total
Revenue from Contract with Customer, Excluding Assessed Tax
Product revenue, net
Total revenues
Statement of Comprehensive Income [Abstract]
Selling, General and Administrative Expense, Total
Selling, General and Administrative Expense
Selling, general and administrative
Credit Facility
Credit Facility [Domain]
Andrew J. Grethlein, Ph.D.
Andrew J. Grethlein, Ph.D. [Member]
Andrew J. Grethlein, Ph.D.
Debt Securities Available For Sale [Table]
Debt Securities, Available-for-Sale [Table]
Increase (Decrease) in Stockholders' Equity
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Depreciation, Depletion and Amortization, Nonproduction, Total
Depreciation and amortization
Depreciation, Depletion and Amortization, Nonproduction
Number of warrants exercised during the period
Class Of Warrant Or Right Number Of Securities Called By Warrants Or Rights Exercised
Warrants to purchase common stock exercised, shares
Other
Other Accrued Liabilities, Current
Entity Address, Address Line Two
Entity Address, Address Line Two
Assumptions used to estimate fair value of awards
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions and Methodology [Abstract]
LIABILITIES AND STOCKHOLDERS' EQUITY
Liabilities and Equity [Abstract]
Document Period End Date
Document Period End Date
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Term loan interest rate description
Debt Instrument, Interest Rate, Basis for Effective Rate
Litigation settlement, amount
Litigation Settlement, Amount Awarded to Other Party
Stockholders' Equity Note [Abstract]
Public Offering Of Common Stock And Warrants [Member]
Public Offering of Common Stock and Warrants [Member]
Public Offering of Common Stock and Warrants
Public Offering of Common Stock and Warrants
Potential dilutive securities excluded from diluted earnings (loss) per share calculation (in shares)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Depreciation [Abstract]
Depreciation [Abstract]
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Stock-based compensation for equity-based awards to employees and directors
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Accrued liabilities
Accrued liabilities
Accrued Liabilities, Current
Tranche four.
Tranche Four [Member]
Marketable securities:
Debt Securities, Available-for-Sale [Abstract]
Trading Symbol
Trading Symbol
Variable Rate [Axis]
Total stockholders' equity
Balances
Balances
Equity, Attributable to Parent
Summary of Investment Holdings [Line Items]
2018 Plan
Two Thousand And Eighteen Equity Incentive Plan [Member]
2018 equity incentive plan.
2018 Equity Incentive Plan
Common stock outstanding warrants to purchase
Class of Warrant or Right, Outstanding
Stock-Based Compensation
Share-Based Payment Arrangement [Policy Text Block]
Deposits and other assets
Deposits And Other Assets Noncurrent
Carrying value of amounts transferred to third parties for security purposes that are expected to be returned or applied towards payment after one year or beyond the operating cycle, if longer; and amount of noncurrent assets classified as other.
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Abstract]
Royalty Pharma Revenue Participation Right Purchase Agreement
Royalty Pharma Revenue Participation Right Purchase Agreement [Member]
Royalty Pharma Revenue Participation Right Purchase Agreement.
Summary of allocation of stock-based compensation expense included in operating expenses on condensed consolidated statements of operations related to share-based payment awards
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Gross Unrealized Losses
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
At market issuance two thousand and twenty three sales agreement.
At Market Issuance Two Thousand And Twenty Three Sales Agreement [Member]
2023 Sales Agreement
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Purchase Warrants [Member]
Purchase warrants.
Public offering stock issued during period value new issues.
Public Offering Stock Issued During Period Value New Issue
Issuances of common stock and pre-funded warrant to purchase common stock in public offering, net of issuance costs
Expected volatility range, minimum (as a percent)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Sales returns and allowance.
Sales Returns And Allowance [Member]
Sales returns and allowances
Scenario [Axis]
Dividend yield (as a percent)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Security Exchange Name
Security Exchange Name
Debt covenant minimum cash balance
Debt Covenant Minimum Cash Balance
Debt Covenant Minimum Cash Balance
Counterparty Name [Domain]
Total operating expenses
Operating Expenses
Stock Issued During Period, Value, Issued for Services
Stock-based compensation related to issuance of common stock and options for services
Loss Contingency Nature [Axis]
Class of Stock [Axis]
Senior secured term loan facility
Secured Long-Term Debt, Noncurrent
Period of base salary in connection with a non-change of control to be considered for severance payments
Loss Contingency Period Of Current Base Salary To Be Paid Under Severance Plan Non Change of Control Triggering Event
Loss contingency period of current base salary to be paid under severance plan non change of control triggering event.
Settlement Liabilities, Current
Legal settlements
FAIR VALUE MEASUREMENTS
Fair Value Disclosures [Text Block]
Subsequent Event
Subsequent Event [Member]
Maximum [Member]
Maximum
Maximum [Member]
Accrued end of term charges.
Accrued End Of Term Charges
Accrued end of term charge
Investment Holdings [Table]
Total liabilities and stockholders' equity
Liabilities and Equity
Operating leases, right-of-use assets
Operating Lease, Right-of-Use Asset
Earnings Per Share, Diluted, Total
Earnings Per Share, Diluted
Diluted net loss per share
Severance Plan [Table]
Severance Plan [Table]
Severance plan.
Corporate notes (due in less than one year)
Corporate Note Securities Due In Less Than One Year [Member]
This category includes information about short-term debt securities that are issued by either a domestic or foreign corporate business entity with a date certain promise of repayment and a return to the holder for the time value of money (for example, variable or fixed interest), due in less than one year.
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
Chargeback and distributor service fees.
Chargeback And Distributor Service Fees [Member]
Chargebacks and distributor service fees
Total current assets
Assets, Current
Net Cash Provided by (Used in) Investing Activities
Net cash used in investing activities
Scenario Forecast [Member]
Forecast [Member]
Realized Investment Gains (Losses), Total
Realized investment gains (losses)
Realized Investment Gains (Losses)
Vesting period of awards
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Entity Filer Category
Entity Filer Category
Restricted cash:
Restricted Cash and Investments [Abstract]
Payments to Acquire Marketable Securities, Total
Purchases of marketable securities
Payments to Acquire Marketable Securities
Percentage of annual net sales
Percentage of annual net sales.
Current Fiscal Year End Date
Current Fiscal Year End Date
Fair Value on a Recurring Basis
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Second amendment.
Second Amendment [Member]
Equity investment ownership percentage
Equity Investment Ownership Percentage
Equity investment ownership percentage.
Share-based Payment Arrangement, Noncash Expense, Total
Stock-based compensation for employees and directors
Share-Based Payment Arrangement, Noncash Expense
Description of maturity date terms for term loan
Long-Term Debt, Description
2022 Underwritten Public Offering
Two Thousand Twenty Two Underwritten Public Offering [Member]
Information by type of sale of the entity's stock. = 2022 Underwritten Public Offering [Member].
Entity Registrant Name
Entity Registrant Name
Debt Securities, Available-for-sale, Unrealized Loss Position, Accumulated Loss, Total
Total - Gross Unrealized Losses
Debt Securities, Available-for-Sale, Unrealized Loss Position, Accumulated Loss
Interest only period payment term description.
Interest Only Period Payment Term Description
Interest only period payment term description
Scenario Two
Scenario Two [Member]
Scenario two .
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Term loan maturity date
Debt Instrument, Maturity Date
Entity Emerging Growth Company
Entity Emerging Growth Company
Money market funds
Money Market Funds [Member]
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted Average Number of Shares Outstanding, Basic
Shares used in computing basic net loss per share
Vesting [Domain]
Period within which no comparable employment is offered by the entity following a change of control
Loss Contingency Triggering Event Period Following Change Of Control During Which No Comparable Employment Is Offered By Entity
Represents the period following change of control within which an employee is not offered comparable employment (new or continuing) by the entity or its successor or acquired and to be considered as triggering event for severance payments.
Insurance Claims
Insurance Claims [Member]
Hercules Loan Agreement
Hercules Loan Agreement Member
Hercules loan agreement.
Expected volatility range, maximum (as a percent)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Interest payable
Interest Payable, Current
Estimated useful lives of assets
Property, Plant and Equipment, Useful Life
Royalty [Member]
Royalties
Included in cash and cash equivalents:
Cash and Cash Equivalents [Abstract]
Level 1
Fair Value, Inputs, Level 1 [Member]
Debt Disclosure [Abstract]
Financial Instrument
Financial Instrument [Axis]
Net Loss Per Share
Earnings Per Share, Policy [Policy Text Block]
Manufacturing activities
Accrued Manufacturing Activities Current
Carrying value as of the balance sheet of obligations incurred through the date and payable for manufacturing related costs. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Debt Issuance Costs and Debt Discounts
Debt, Policy [Policy Text Block]
General and administrative
General and Administrative Expense
General and Administrative Expense [Member]
Government rebates.
Government Rebates [Member]
Government rebates
Debt, Current, Total
Debt, Current
Debt
Tranche Six [Member]
Tranche Six [Member]
Tranche six.
Option one min cash debt covenant.
Option one min cash debt covenant [Member]
Option One Min Cash Debt Covenant [Member]
Shares Issued, Value, Share-based Payment Arrangement, after Forfeiture, Total
Shares Issued, Value, Share-Based Payment Arrangement, after Forfeiture
Issuance of common stock under equity plans
Employees Above The Vice President Level
Employees Above The Vice President Level [Member]
Employees above the vice president level.
Gross Unrealized Losses
Restricted Cash And Cash Equivalents Gross Unrealized Losses
Restricted cash and cash equivalents gross unrealized losses.
Debt Securities, Available-for-sale, Total
Estimated Fair Value
Debt Securities, Available-for-Sale
Accounting Policies [Abstract]
Depreciation and Amortization
Depreciation, Depletion, and Amortization [Policy Text Block]
Stockholders' equity:
Equity, Attributable to Parent [Abstract]
Tranche Five [Member]
Tranche Five [Member]
Tranche five.
Raw materials
Inventory, Raw Materials and Supplies, Gross
Inventory, Raw Materials and Supplies, Gross, Total
Restricted Cash
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Statement [Table]
Statement [Table]
Segment Information
Segment Reporting, Policy [Policy Text Block]
Warrants to purchase common stock exercised, shares
Class Of Warrants Or Right Number Of Securities Called By Warrants Or Rights Exercised
Class of warrants or right number of securities called by warrants or rights exercised.
Subsequent Event [Table]
4th Anniversary Of Funding Date
Prepaid On Or After Fourth Anniversary Of Funding Date [Member]
Prepaid on or after fourth anniversary of funding date.
Revenue interest payments
Revenue from Contract with Customer, Including Assessed Tax
Entity File Number
Securities Act File Number
Net increase in cash, cash equivalents and restricted cash
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Revenue from Contract with Customer [Abstract]
Remainder of 2024
Long-Term Debt, Maturity, Remainder of Fiscal Year
Inventory Disclosure [Abstract]
Statement of Financial Position [Abstract]
Interest Expense, Total
Interest expense
Interest Expense, Operating and Nonoperating
Loss from operations
Operating Income (Loss)
2025
Long-Term Debt, Maturity, Year One
Combined public offering price per share of common stock and accompanying stock purchase warrants
Shares Issued, Price Per Share
Public offering price of common stock per share
Schedule of assumptions used to estimate the fair value of employee stock purchases under the purchase plan
Schedule of Share-Based Payment Award, Employee Stock Purchase Plan, Valuation Assumptions [Table Text Block]
Entity Shell Company
Entity Shell Company
Professional legal and accounting fees
Accrued Professional Fees, Current
Effective interest rate
Debt Instrument, Interest Rate, Effective Percentage
Entity Tax Identification Number
Entity Tax Identification Number
ASSETS
Assets [Abstract]
Fair Value of Financial Instruments
Fair Value of Financial Instruments, Policy [Policy Text Block]
Entity Current Reporting Status
Entity Current Reporting Status
Amortized Cost
Restricted cash
Restricted Cash and Cash Equivalents, Current
Subsequent Events [Abstract]
Inventory Disclosure [Text Block]
INVENTORY
3rd Anniversary Of Funding Date
Prepaid Prior To Third Anniversary Of Funding Date [Member]
Prepaid prior to third anniversary of funding date.
Revenue Recognition
Revenue from Contract with Customer [Policy Text Block]
Document Fiscal Year Focus
Document Fiscal Year Focus
Gross Unrealized Gains
Cash And Cash Equivalents Unrealized Gains
Represents the gross unrealized gains for cash and cash equivalents.
Certificate of deposit
Certificates of Deposit [Member]
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Cash, cash equivalents and restricted cash at the beginning of the period
Cash, cash equivalents and restricted cash at the end of the period
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Cost of Goods and Service [Policy Text Block]
Cost of Goods Sold
City Area Code
City Area Code
Prior Period Reclassification
Reclassification, Comparability Adjustment [Policy Text Block]
OCI, Debt Securities, Available-for-Sale, Gain (Loss), before Adjustment, after Tax, Total
OCI, Debt Securities, Available-for-Sale, Gain (Loss), before Adjustment, after Tax
Other comprehensive income (loss)
Total current liabilities
Liabilities, Current
Gross Unrealized Gains
Restricted Cash And Cash Equivalents Unrealized Gains
Restricted cash and cash equivalents unrealized gains.
Inventory, Net
Inventory
Total inventory
Equity Investment
Equity Securities [Member]
Inventory, Finished Goods, Gross
Finished goods
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Local Phone Number
Local Phone Number
Period within which employee resigns following a change of control due to material change in terms of employment
Loss Contingency Triggering Event Period Following Change Of Control Within Which Employee Resigns Due To Material Change In Terms Of Employment
Represents the period within which employee resigns following a change of control due to material change in terms of employment and to be considered as triggering event for severance payments.
Faye M. Feller, M.D.
Faye M. Feller, M.D [Member]
Faye M. Feller, M.D.
Antidilutive Securities Excluded from Computation of Earnings Per Share
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Less Than 12 Months - Gross Unrealized Losses
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months, Accumulated Loss
Tranche two.
Tranche Two [Member]
Proceeds from exercise of warrants
Proceeds from Warrant Exercises
Commitments and Contingencies Disclosure [Abstract]
Business Combination Cost Of Acquired Entity Equity Interests Issued And Issuable Fair Value Method
Business Combination, Consideration Transferred, Equity Interests Issued and Issuable Fair Value Method
Amortized Cost
Debt Securities, Available-for-Sale, Amortized Cost
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Other Increases (Decreases) in Period
Common stock, increase in shares reserved for future issuance (in shares)
Common stock, increase in option reserves (in shares)
Operating lease liabilities
Operating Lease, Liability, Current
Tranche C
Tranche C [Member]
Tranche C [Member]
Tranche C [Member]
Foreign currency translation adjustments
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Total
Foreign currency translation adjustment
Foreign currency translation adjustment
Stated interest rate
Debt Instrument, Interest Rate, Stated Percentage
Debt instrument face amount expired
Debt Instrument Face Amount Expired
Debt instrument face amount expired.
Accumulated Deficit
Retained Earnings [Member]
Amortization of Debt Issuance Costs and Discounts, Total
Amortization of Debt Issuance Costs and Discounts
Amortization of debt issuance costs/debt discounts
Payments to Acquire Property, Plant, and Equipment, Total
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment
Document Transition Report
Document Transition Report
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Antidilutive Security, Excluded EPS Calculation [Table]
Tranche three.
Tranche Three [Member]
Proceeds from Stock Plans
Proceeds from employee stock purchase plan
Option three min cash debt covenant.
Option three min cash debt covenant [Member]
Option Three Min Cash Debt Covenant [Member]
Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net, Total
Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net
Less: unamortized debt discounts and issuance costs
Minimum [Member]
Minimum
Minimum [Member]
Common Stock
Common Stock [Member]
Stock-Based Compensation Expense
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
ACCRUED LIABILITIES
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
U.S. Treasury securities (due in less than one year)
U S Treasury Securities Due In Less Than One Year [Member]
US Treasury Securities Due In less than one Year Member.
Amortization of right-of-use assets
Operating Lease, Right-of-Use Asset, Periodic Reduction
Additional Paid-In Capital
Additional Paid-in Capital [Member]
Debt Securities, Available-for-sale, Current, Total
Marketable securities
Debt Securities, Available-for-Sale, Current
Two thousand twenty three pre funded warrant.
Two Thousand Twenty Three Pre Funded Warrant Member
2023 Pre-funded Warrant
Income Statement Location
Statement of Income Location, Balance [Domain]
2023 Underwritten Public Offering.
Two Thousand Twenty Three Underwritten Public Offering [Member]
2023 Public Offering
Government-sponsored enterprise securities (due in one to two years)
U S Government Sponsored Enterprises Debt Securities Due In One To Two Years [Member]
Represents information pertaining to debentures, bonds and other debt securities issued by US government sponsored entities (GSEs), for example, but not limited to, Federal Home Loan Mortgage Corporation (FHLMC or Freddie Mac), Federal National Mortgage Association (FNMA or Fannie Mae), and the Federal Home Loan Bank (FHLB). Excludes debt issued by the Government National Mortgage Association (GNMA or Ginnie Mae), due in one to two years.
Two thousand twenty two pre-funded warrants.
Two Thousand Twenty Two Pre Funded Warrants [Member]
2022 Pre-Funded Warrant
Schedule of Inventory, Current [Table Text Block]
Schedule of Inventory
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Disaggregation of Revenue [Line Items]
Less Than 12 Months - Estimated Fair Value
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months
Basis of Presentation
Basis of Accounting, Policy [Policy Text Block]
Common stock exercised to warrants purchase
Warrants Issued Shares
Warrants issued shares.
Scenario [Domain]
Title and Position [Domain]
Issuance costs
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs
Debt Securities, Available-for-Sale, Allowance for Credit Loss, Total
Debt Securities, Available-for-Sale, Allowance for Credit Loss, Beginning Balance
Debt Securities, Available-for-Sale, Allowance for Credit Loss, Ending Balance
Debt Securities, Available-for-Sale, Allowance for Credit Loss
Allowances for credit losses on available-for-sale securities
Common Stock, Value, Issued, Ending Balance
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Total
Common stock
Common Stock, Value, Issued
Prepayment premium on percentage of term loan
Prepayment Premium on Percentage of Term Loan
The prepayment premium on percentage of term loan.
Interest income
Investment Income, Interest
Proceeds from issuance of common stock and warrants in public offering, net of paid issuance costs
Proceeds From Public Offering Issuance Of Common Stock And Warrants
Proceeds from public offering issuance of common stock and warrants.
Proceeds from issuance of common stock from public offering and pre-funded warrant, net of paid issuance costs
Estimated Fair Value
Cash and Cash Equivalents, Fair Value Disclosure
Percentage of outstanding loan amount payable upon maturity.
Debt Instrument End Of Term Charge Percentage
End of term charge for loan, percentage
Stock-based compensation for equity-based awards to employees and directors (in shares)
Adjustments To Additional Paid In Capital Share Based Compensation Requisite Service Period Recognition Shares
Adjustments to additional paid in capital share based compensation requisite service period recognition shares.
Measurement Frequency
Measurement Frequency [Axis]
Schedule of accrued liabilities
Schedule of Accrued Liabilities [Table Text Block]
Commitments and contingencies
Commitments and Contingencies
Public Offering Stock Issued During Period Shares New Issues
Public offering stock issued during period shares new issues.
Issuances of common stock and pre-funded warrant to purchase common stock in public offering, net of issuance costs (in shares)
Effect Of Unrealized Losses And Exchange Rate On Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
Amount of increase (decrease) from effect of unrealized losses and exchange rate changes on cash and cash equivalents, and cash and cash equivalents restricted to withdrawal or usage; held in foreign currencies; including, but not limited to, disposal group and discontinued operations. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. Cash equivalents include, but are not limited to, short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates.
Effect of exchange rates on cash, cash equivalents and restricted cash
12 Months or Longer - Gross Unrealized Losses
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer, Accumulated Loss
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted Average Number of Shares Outstanding, Diluted
Shares used in computing diluted net loss per share
Research and development
Research and Development Expense (Excluding Acquired in Process Cost)
Accounts Receivable, after Allowance for Credit Loss, Current, Total
Accounts Receivable, after Allowance for Credit Loss, Current
Accounts receivable, net
Increase (Decrease) in Inventories, Total
Increase (Decrease) in Inventories
Inventory
Period of base salary to be considered for severance payments
Loss Contingency Period Of Current Base Salary To Be Paid Under Severance Plan
Loss contingency period of current base salary to be paid under severance plan.
2022 Stock Purchase Warrants
Two Thousand Twenty Two Stock Purchase Warrants [Member]
2022 Stock Purchase Warrants.
Warrants expiration date
Warrants and Rights Outstanding, Maturity Date
Corporate notes (due in one to two years)
Corporate Note Securities Due In One To Two Years [Member]
This category includes information about short-term debt securities that are issued by either a domestic or foreign corporate business entity with a date certain promise of repayment and a return to the holder for the time value of money (for example, variable or fixed interest), due in one to two years.
Entity Small Business
Entity Small Business
Spread on variable rate
Percentage added to prime rate for debt instrument interest rate
Debt Instrument, Basis Spread on Variable Rate
DEBT
Debt Disclosure [Text Block]
Remaining amount drawn down under Tranche A term loan
Second Draw Down Under Tranche A Term Loan
Amount for second draw down under Tranche A term loan
Stock Issued During Period, Shares, Issued for Services
Stock-based compensation related to issuance of common stock and options for services (in shares)
Schedule of cash equivalents, restricted cash and marketable securities by security type
Fair Value, by Balance Sheet Grouping [Table Text Block]
Proceeds, Issuance of Shares, Share-based Payment Arrangement, Including Option Exercised, Total
Proceeds from issuances of common stock from equity plans
Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Including Option Exercised
Equity investment reverse stock split
Equity Investment Reverse Stock Split
Reverse stock split ratio for equity investment.
Credit Facility
Credit Facility [Axis]
Accretion and amortization on investments, net
Accretion (Amortization) of Discounts and Premiums, Investments
Estimated Fair Value
Restricted Investments, at Fair Value
Adjustment to additional paid in capital offering expenses.
Adjustment to Additional Paid In Capital Offering Expenses
Offering expenses
Cash flows from financing activities:
Net Cash Provided by (Used in) Financing Activities [Abstract]
Asset Class
Asset Class [Axis]
Pre-funded warrants purchase.
Pre Funded Warrants Purchase [Member]
Pre-Funded Warrants
Measurement Frequency
Measurement Frequency [Domain]
Percentage of net product revenue.
Percentage of Net Product Revenue
Percentage of net product revenue
Work-in-process
Inventory, Work in Process, Gross
Level 3
Fair Value, Inputs, Level 3 [Member]
SUBSEQUENT EVENTS
Subsequent Events [Text Block]
Employee Stock Purchase Plan
Stock options and warrants excluded from diluted net loss per share calculation due to net loss position
Share-Based Payment Arrangement [Member]
Securities class action settlement
Securities Class Action Settlement
Securities class action settlement.
Accounts Payable, Current, Total
Accounts payable
Accounts Payable, Current
Repayment of line of credit
Repayments of Long-Term Lines of Credit
SOFR
Secured Overnight Financing Rate (SOFR) [Member]
Accounts Payable and Accrued Liabilities, Current, Total
Accounts Payable and Accrued Liabilities, Current
Accounts payable and accrued expenses