Interest and other receivables Nontrade Receivables, Current Scenario Two Scenario Two [Member] Scenario two . Award Timing Predetermined Award Timing Predetermined [Flag] Entity File Number Entity File Number Additional Paid-In Capital Additional Paid-in Capital [Member] Federal and state tax credits Effective Income Tax Rate Reconciliation, Tax Credit, Amount Commercial paper (due in less than one year) Commercial Paper Due In Less Than One Year [Member] Represents information pertaining to unsecured promissory note (generally negotiable) that provides institutions with short-term funds ), due in less than one year. Tabular List, Table Tabular List [Table Text Block] Operating lease liabilities Increase (Decrease) In Operating Lease Liabilities Increase decrease in operating lease liabilities. Recent Accounting Pronouncements New Accounting Pronouncements, Policy [Policy Text Block] Prepayment premium on percentage of term loan Prepayment Premium On Percentage Of Term Loan The prepayment premium on percentage of term loan. Schedule of Cash Equivalents, Restricted Cash and Marketable Securities Fair Value, by Balance Sheet Grouping [Table Text Block] Royalty financing obligation Royalty payments Payments for Royalties Employee Stock Purchase Plan Employee stock purchase plan Share-Based Payment Arrangement [Member] Adjustment to Compensation: Adjustment to Compensation [Axis] Named Executive Officers, Footnote Named Executive Officers, Footnote [Text Block] PRODUCT REVENUE Revenue from Contract with Customer [Text Block] Stock-based compensation Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost Employee stock purchase (in shares) Stock Issued During Period, Shares, Employee Stock Purchase Plans Prepaid Prior To Third Anniversary Of Funding Date Prepaid Prior To Third Anniversary Of Funding Date [Member] Prepaid prior to third anniversary of funding date. Gross Unrealized Losses Cash And Cash Equivalents Unrealized Losses Represents the gross unrealized losses for cash and cash equivalents. Adjustment to Compensation, Amount Adjustment to Compensation Amount Concentration risk, percentage Concentration Risk, Percentage Less: unamortized debt discount and issuance costs Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net Principles of Consolidation Consolidation, Policy [Policy Text Block] Stock-based compensation for employees and directors Share-Based Payment Arrangement, Noncash Expense Stock Options Share-Based Payment Arrangement, Option [Member] Stock options to be granted to purchase shares upon appointment (in shares) Share Based Compensation Arrangement By Share Based Payment Award Options To Be Granted To Purchase Shares Upon Appointment Represents the number of options to be granted to purchase shares upon appointment to Board of Directors. Schedule Of Property Plant And Equipment [Table] Property, Plant and Equipment [Table] Cash Equivalents Cash and Cash Equivalents, Policy [Policy Text Block] Percentage Effective Income Tax Rate Reconciliation, Percent [Abstract] Maximum expiration term of stock options granted to employees having more than 10 % outstanding common stock Share Based Compensation By Share Based Payment Award Options Maximum Expiration Term For Options Granted To Optionees With Ownership Of More Than10 Percentage Of Common Stock Represents the maximum expiration term of options granted to employees having more than 10 % outstanding common stock. Capitalized research and development Deferred Tax Assets, Capitalized Research And Development Amount before allocation of valuation allowances of deferred tax asset attributable to the treatment of research and development costs. Antidilutive Securities Antidilutive Securities [Axis] Total stockholders' equity Balance at beginning of period Balance at end of period Equity, Attributable to Parent Debt Securities Available For Sale [Table] Debt Securities, Available-for-Sale [Table] Insider Trading Policies and Procedures [Line Items] Schedule of Property and Equipment Property, Plant and Equipment [Table Text Block] Common stock, authorized (in shares) Common Stock, Shares Authorized Issuance of common stock in connection with at market offering, net of issuance costs (in shares) Stock Issued During Period, Shares, New Issues Concentration of Credit Risk Concentration Risk, Credit Risk, Policy [Policy Text Block] LIABILITIES AND STOCKHOLDERS' EQUITY Liabilities and Equity [Abstract] State State and Local Jurisdiction [Member] Cover Cover [Abstract] Restructuring and related cost, incurred cost Restructuring and Related Cost, Incurred Cost Estimated Fair Value Cash and Cash Equivalents, Fair Value Disclosure Maximum Maximum [Member] Stock options exercisable at the end of the period (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price Total Debt Securities, Available-for-Sale, Unrealized Loss Position Government-sponsored enterprise securities (due in less than one year) U S Government Sponsored Enterprises Debt Securities Due In Less Than One Year [Member] Represents information pertaining to debentures, bonds and other debt securities issued by US government sponsored entities (GSEs), for example, but not limited to, Federal Home Loan Mortgage Corporation (FHLMC or Freddie Mac), Federal National Mortgage Association (FNMA or Fannie Mae), and the Federal Home Loan Bank (FHLB). Excludes debt issued by the Government National Mortgage Association (GNMA or Ginnie Mae, due in less than one year. Restricted stock awards Restricted Stock [Member] Period of base salary to be considered for severance payments Loss Contingency, Period Of Current Base Salary To Be Paid Under Severance Plan Loss contingency period of current base salary to be paid under severance plan. 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Accrued vacation Accrued Vacation, Current Increase (decrease) in valuation allowance Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year [Member] Minimum percentage of ownership required for granting stock options at least 110% of fair market value of common stock Share Based Compensation Arrangement By Share Based Payment Award Minimum Percentage Of Ownership Required For Granting Options At Minimum110 Percent Of Fair Market Value Represents the minimum percentage of ownership required for granting of options at a price not less than 110 percent of the fair market value of common stock. Net proceeds from public offering after deducting underwriting discount and other offering expenses Proceeds from Issuance or Sale of Equity Prepaid and other current assets Prepaid Expense and Other Assets, Current Effective interest rate Debt Instrument, Interest Rate, Effective Percentage Entity Address, Postal Zip Code Entity Address, Postal Zip Code Restatement Determination Date Restatement Determination Date Effective tax rate Income Tax Expense (Benefit) Stock options to be granted to purchase shares (in shares) Share Based Compensation Arrangement By Share Based Payment Award Options To Be Granted To Purchase Shares Represents the number of options to be granted to purchase shares in each year during the optionee's service on the Board of Directors. Percentage added to prime rate for debt instrument interest rate Debt Instrument, Basis Spread on Variable Rate BioPharma Credit PLC BioPharma Credit PLC [Member] BioPharma credit PLC. Common stock, increase in shares reserved for future issuance (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Other Increases (Decreases) in Period Preferred stock, issued (in shares) Preferred Stock, Shares Issued Pension Adjustments Service Cost Pension Adjustments Service Cost [Member] Fair Value Hierarchy and NAV Fair Value Hierarchy and NAV [Axis] Property and equipment, gross Property, Plant and Equipment, Gross Cancelable commercial purchase commitments Recorded Unconditional Purchase Obligation RESTRUCTURING Restructuring and Related Activities Disclosure [Text Block] Amortization of right-of-use assets Operating Lease, Right-of-Use Asset, Periodic Reduction Compensation Actually Paid vs. Company Selected Measure Compensation Actually Paid vs. Company Selected Measure [Text Block] Cash received from exercise of stock options Proceeds from Stock Options Exercised All Trading Arrangements All Trading Arrangements [Member] Equity Awards Adjustments, Footnote Equity Awards Adjustments, Footnote [Text Block] Total Shareholder Return Vs Peer Group Total Shareholder Return Vs Peer Group [Text Block] Stock options fully vested and expected to vest at the end of the period Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term Accrued liabilities Accrued liabilities Accrued Liabilities, Current Proceeds from issuance of common stock and warrants in public offering, net of paid issuance costs Proceeds From Public Offering Issuance Of Common Stock And Warrants Proceeds from public offering issuance of common stock and warrants. Other Effective Income Tax Rate Reconciliation, Other Adjustments, Amount Unvested, beginning balance (in shares) Unvested, ending balance (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Abstract] Debt Instrument, Scenario [Domain] Debt Instrument, Scenario [Domain] Debt Instrument, Scenario [Domain] Net cash used in operating activities Cash Provided by (Used in) Operating Activity, Including Discontinued Operation Liability Related to Sale of Future Royalties Royalty Pharma Revenue Participation Right Purchase Agreement [Member] Royalty Pharma Revenue Participation Right Purchase Agreement. Tranche A Tranche A [Member] Tranche A [Member] Marketable securities Debt Securities, Available-for-Sale, Excluding Accrued Interest Government rebates Government Rebates [Member] Government rebates. Estimated useful lives of assets Property, Plant and Equipment, Useful Life Preferred stock, par value (in dollars per share) Preferred Stock, Par or Stated Value Per Share Subsequent Event Subsequent Event [Member] Schedule of Assumptions Used to Estimate the Fair Value of Stock Options Granted Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Equity Valuation Assumption Difference, Footnote Equity Valuation Assumption Difference, Footnote [Text Block] PEO Total Compensation Amount PEO Total Compensation Amount Stock options fully vested and expected to vest at the end of the period (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price Money market funds Money Market Funds [Member] Period within which no comparable employment is offered by the entity following a change of control Loss Contingency, Triggering Event Period Following Change Of Control During Which No Comparable Employment Is Offered By Entity Represents the period following change of control within which an employee is not offered comparable employment (new or continuing) by the entity or its successor or acquired and to be considered as triggering event for severance payments. Equity Components Equity Components [Axis] Property Plant And Equipment [Line Items] Property, Plant and Equipment [Line Items] Issuance of common stock in connection with exercise of warrants (in shares) Issuance Of Common Stock In Connection With Warrant Exercise Shares Number of new shares issued during the period in connection with exercise of warrants. Non-Rule 10b5-1 Arrangement Adopted Non-Rule 10b5-1 Arrangement Adopted [Flag] Product revenue, net Product revenues, net Product [Member] Number of reportable segment Number of Reportable Segments Entity Address, State or Province Entity Address, State or Province Total current liabilities Liabilities, Current Restructuring and related cost, number of positions eliminated, period percent Restructuring and Related Cost, Number of Positions Eliminated, Period Percent Aggregate Intrinsic Value Share Based Compensation Arrangement By Share Based Payment Award Options Intrinsic Value [Abstract] Aggregate Intrinsic Value Individual: Individual [Axis] Income Tax Authority Income Tax Jurisdiction [Domain] Document Annual Report Document Annual Report Research and development Research and Development Expense [Member] Forgone Recovery, Explanation of Impracticability Forgone Recovery, Explanation of Impracticability [Text Block] Repayment of debt Repayments of Long-Term Debt Entity Interactive Data Current Entity Interactive Data Current Interest and other receivables Increase (Decrease) In Accrued Interest Receivable Net And Other Receivables The increase (decrease) during the reporting period in the amount due for interest payments related to marketable securities and in other amounts due to the reporting entity, which are not otherwise defined in the taxonomy. Issuance of common stock in connection with public offering (in shares) Share Of Common Stock Issued During Period Shares New Issues Public Offering Number of new shares of common stock issued during the period in connection with public offering. First Director Option First Director Option [Member] Represents information pertaining to the stock options to be granted by the entity to a person who first becomes a non-employee director. Corporate notes (due in one to two years) Corporate Note Securities Due In One To Two Years [Member] This category includes information about short-term debt securities that are issued by either a domestic or foreign corporate business entity with a date certain promise of repayment and a return to the holder for the time value of money (for example, variable or fixed interest), due in one to two years. Revenue Recognition Revenue from Contract with Customer [Policy Text Block] Stock options exercisable at the end of the period Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value Stock-based compensation Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Amount U.S. Treasury securities US Treasury Notes Securities [Member] Disaggregation of Revenue [Table] Disaggregation of Revenue [Table] Net operating loss carryforwards Deferred Tax Assets, Operating Loss Carryforwards Long-Lived Tangible Asset Long-Lived Tangible Asset [Axis] Class of Warrant or Right [Table] Class of Warrant or Right [Table] Hercules and Silicon Valley Bank Hercules And Silicon Valley Bank [Member] Hercules and Silicon Valley Bank. member. Distributor service fees Distributor Service Fees [Member] Distributor Service Fees 2026 Sales Agreement 2026 Sales Agreement [Member] 2026 Sales Agreement Interest payable Interest Payable, Current Customer [Domain] Customer [Domain] Entity Central Index Key Entity Central Index Key PEO Name PEO Name Schedule of Future Minimum Payments Under Term Loan Facility Schedule of Maturities of Long-Term Debt [Table Text Block] Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year [Member] Research and development Research and Development Expense [Abstract] Supplemental Cash Flow Elements [Abstract] Supplemental Cash Flow Elements [Abstract] Issuance of common stock in connection with exercise of warrants Issuance Of Common Stock In Connection With Warrant Exercise Value Equity impact of the value of stock issued in connection with exercise of warrants during the period. Outstanding Aggregate Erroneous Compensation Amount Outstanding Aggregate Erroneous Compensation Amount State State and Local Income Tax Expense (Benefit), Continuing Operations FINANCIAL INSTRUMENTS Financial Instruments Disclosure [Text Block] Warrants exercise price (in dollars per share) Class of Warrant or Right, Exercise Price of Warrants or Rights Work-in-process Inventory, Work in Process, Net of Reserves Exercise Price Award Exercise Price Entity Filer Category Entity Filer Category Tax at statutory rate Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent Subsequent Event Type Subsequent Event Type [Axis] Foreign Foreign Income Tax Expense (Benefit), Continuing Operations Noncurrent debt Noncurrent portion of debt Long-Term Debt, Excluding Current Maturities Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year [Member] Entity Address, Address Line One Entity Address, Address Line One Entity Address, Address Line Two Entity Address, Address Line Two Accumulated Other Comprehensive Income (Loss) AOCI Attributable to Parent [Member] Customer Three Customer Three [Member] Customer Three Fair Value as of Grant Date Award Grant Date Fair Value Proceeds from exercise of warrants Proceeds from Warrant Exercises Net operating loss carryforwards Operating Loss Carryforwards Change in unrecognized tax benefit Effective Income Tax Rate Reconciliation, Tax Contingency, Amount 2023 Pre-funded Warrant Two Thousand Twenty Three Pre Funded Warrant [Member] Two thousand twenty three pre funded warrant. Granted (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period Title and Position [Domain] Title and Position [Domain] Forfeited (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period Compensation cost not yet recognized, net of estimated forfeitures Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount Sale of future royalties Carrying value of liability related to sale of future royalties at beginning of period Carrying value of liability related to sale of future royalties at end of period Accrued Royalties Less Than 12 Months Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months Changed Peer Group, Footnote Changed Peer Group, Footnote [Text Block] Selling, general and administrative Selling, General and Administrative Expense [Abstract] Counterparty Name Counterparty Name [Domain] Stock Purchase Warrants Stock Purchase Warrants [Member] Stock purchase warrants. 2027 Lessee, Operating Lease, Liability, to be Paid, Year Two Government-sponsored enterprise securities US Government-sponsored Enterprises Debt Securities [Member] Investments, All Other Investments [Abstract] Adjustment To PEO Compensation, Footnote Adjustment To PEO Compensation, Footnote [Text Block] Ending balance Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Title Trading Arrangement, Individual Title Peer Group Total Shareholder Return Amount Peer Group Total Shareholder Return Amount Non-PEO NEO Non-PEO NEO [Member] Ending balance Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value Issuances of common stock under employee stock purchase plan Stock Issued During Period, Value, Employee Stock Purchase Plan Hercules Loan Agreement Hercules Loan Agreement [Member] Hercules loan agreement. Sale of Stock Sale of Stock [Axis] Prepaid On Or After Third Anniversary But Prior To Fourth Anniversary Of Funding Date Prepaid On Or After Third Anniversary But Prior To Fourth Anniversary Of Funding Date [Member] Prepaid on or after third anniversary but prior to fourth anniversary of funding date. 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Accrued revenue adjustments Accrued Revenue Adjustments, Current Accrued Revenue Adjustments, Current Preferred stock, outstanding (in shares) Preferred Stock, Shares Outstanding Document Transition Report Document Transition Report Summary of Investment Holdings [Line Items] Summary of Investment Holdings [Line Items] Underlying Securities Award Underlying Securities Amount Corporate notes Corporate Note Securities [Member] Estimated Fair Value Restricted Investments, at Fair Value Equity Component Equity Component [Domain] Document Period End Date Document Period End Date Cash and Cash Equivalents [Domain] Cash and Cash Equivalents [Domain] INCOME TAXES Income Tax Disclosure [Text Block] At Market Issuance Sales Agreements [Table] At Market Issuance Sales Agreements [Table] At Market Issuance Sales Agreements. Awards Close in Time to MNPI Disclosures, Table Awards Close in Time to MNPI Disclosures [Table Text Block] Commercial expenses Commercial Expenses [Member] Commercial expenses. Stock options exercisable at the end of the period Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term 2025 Underwritten Public Offering Two Thousand Twenty Five Underwritten Public Offering [Member] Two Thousand Twenty Five Underwritten Public Offering Document Type Document Type Level 3 Fair Value, Inputs, Level 3 [Member] Estimated Fair Value Debt Securities, Available-for-Sale, Unrealized Loss Position [Abstract] NET LOSS PER COMMON SHARE Earnings Per Share [Text Block] Name Outstanding Recovery, Individual Name Product and Service [Axis] Product and Service [Axis] Variable lease costs Variable Lease, Cost Revenues Product revenues, net Total revenues Revenue from Contract with Customer, Excluding Assessed Tax Stock options fully vested and expected to vest at the end of the period (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number Total current assets Assets, Current Statistical Measurement Statistical Measurement [Axis] Loss contingency, new claims filed Loss Contingency, New Claims Filed, Number Aggregate Erroneous Compensation Amount Aggregate Erroneous Compensation Amount Total pretax intrinsic value of stock options exercised Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value Peer Group Issuers, Footnote Peer Group Issuers, Footnote [Text Block] Public Offering [Table] Public Offering [Table] Public offering. Current liabilities: Liabilities, Current [Abstract] Total costs and operating expenses Operating Expenses Risk-free interest rate range, minimum Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum Period within which employee is terminated by entity without cause following a change of control Loss Contingency, Triggering Event Employee Termination Without Cause Following Change Of Control Period Represents the number of months following a change in control when an employee is terminated without cause to be classified as a triggering event for severance payments. 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Federal Domestic Tax Jurisdiction [Member] Less: imputed interest Lessee, Operating Lease, Liability, Undiscounted Excess Amount Principal amount outstanding under term loan Total Long-Term Debt, Gross Stock options granted (in dollars per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Entity Well-known Seasoned Issuer Entity Well-known Seasoned Issuer Gross product revenue Revenues Before Adjustments [Member] Revenues before adjustments. Accrued compensation and benefits Accrued compensation and benefits Employee-related Liabilities, Current PROPERTY AND EQUIPMENT Property, Plant and Equipment Disclosure [Text Block] Total lease payments Lessee, Operating Lease, Liability, to be Paid Net unrealized loss (gain) on marketable securities OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax Foster City Office Space Lease Foster City Office Space Lease [Member] Foster City office space lease. Schedule of Cash Equivalents and Marketable Securities with Unrealized Losses Debt Securities, Available-for-Sale, Unrealized Loss Position, Fair Value [Table Text Block] Expiration Date Trading Arrangement Expiration Date Property and equipment, net Property and equipment, net Property, Plant and Equipment, Net Restructuring charges Expenses Restructuring Charges Prepaid On Or After Fourth Anniversary Of Funding Date Prepaid On Or After Fourth Anniversary Of Funding Date [Member] Prepaid on or after fourth anniversary of funding date. Compensation Actually Paid vs. Net Income Compensation Actually Paid vs. Net Income [Text Block] Accounts receivable, net Increase (Decrease) in Accounts Receivable Inventory Inventory, Policy [Policy Text Block] Entity Current Reporting Status Entity Current Reporting Status Awards Close in Time to MNPI Disclosures Awards Close in Time to MNPI Disclosures [Table] Tax at statutory rate Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount Financial Instrument Financial Instrument [Axis] Adjustments to reconcile net loss to net cash used in operating activities: Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Noncash Item [Abstract] Statement of Financial Position [Abstract] Statement of Financial Position [Abstract] Executive Category: Executive Category [Axis] 12 Months or Longer Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer, Accumulated Loss Stock-based compensation Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent State income tax, net of federal benefit Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent Proceeds from debt financing, net of paid debt issuance costs and debt discounts Proceeds from Issuance of Long-Term Debt Current Fiscal Year End Date Current Fiscal Year End Date Percentage of annual net sales Percentage Of Annual Net Sales Percentage of annual net sales. Expected term range Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term Less Than 12 Months Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months, Accumulated Loss Aggregate shares issued under plan (in shares) Share-Based Compensation Arrangement By Share Based Payment Award, Aggregate Shares Issued Under Plan Represents the aggregate number of share instruments issued under a share-based compensation plan. Weighted Average Grant Date Fair Value Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] Shares available for grant (in shares) Stock options and awards available for grant (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant Earnings Per Share, Basic, by Common Class, Including Two-Class Method [Table] Earnings Per Share, Basic, by Common Class, Including Two-Class Method [Table] Weighted average estimated fair value of employee stock options granted (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Equity Awards Adjustments, Excluding Value Reported in Compensation Table Equity Awards Adjustments, Excluding Value Reported in the Compensation Table [Member] Upfront payment received Upfront Payment Received Upfront payment received. Total Debt Securities, Available-for-Sale, Unrealized Loss Position, Accumulated Loss Proceeds from maturities and sales of marketable securities Proceeds from Sale and Maturity of Marketable Securities Beginning balance Ending balance Unrecognized Tax Benefits Included in cash and cash equivalents: Cash and Cash Equivalents [Abstract] TD Securities (USA) LLC TD Securities (USA) LLC [Member] TD Securities (USA) LLC Potential dilutive securities excluded from diluted earnings (loss) per share calculation (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount 2026 Long-Term Debt, Maturity, Year Two OPERATING LEASES Lessee, Operating Leases [Text Block] Net cash provided by financing activities Cash Provided by (Used in) Financing Activity, Including Discontinued Operation Measure: Measure [Axis] Long-Lived Tangible Asset Long-Lived Tangible Asset [Domain] Operating leases, right-of-use assets Deferred Tax Liabilities, Operating Leases, Right Of Use Assets Deferred tax liabilities operating leases right of use assets. Pay vs Performance Disclosure, Table Pay vs Performance [Table Text Block] Forgone Recovery due to Violation of Home Country Law, Amount Forgone Recovery due to Violation of Home Country Law, Amount Entity Tax Identification Number Entity Tax Identification Number Federal and state tax credits Effective Income Tax Rate Reconciliation, Tax Credit, Percent Cash, cash equivalents and restricted cash Cash And Cash Equivalents And Restricted Cash, Fair Value Disclosure Cash And Cash Equivalents And Restricted Cash, Fair Value Disclosure Beginning balance (in dollars per share) Ending balance (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price Common stock, issued (in shares) Common Stock, Shares, Issued 2028 Long-Term Debt, Maturity, Year Four Operating lease, remaining lease term Operating Lease, Weighted Average Remaining Lease Term Maximum commission rate Maximum Commission Rate Represents the percentage of maximum commission rate, based on gross proceeds of sale price per share of common stock sold through sales agent under the sales agreement. Entity Public Float Entity Public Float Interest expense Interest Expense, Nonoperating Trading Arrangement: Trading Arrangement [Axis] Total Shareholder Return Amount Total Shareholder Return Amount Severance Plan Severance Plan [Line Items] Severance plan. Security Exchange Name Security Exchange Name Schedule of Reconciliation of Reported Revenues to Net (Loss) Income Under Significant Expense Principle Reconciliation of Revenue from Segments to Consolidated [Table Text Block] Maximum borrowing capacity under term loan Line of Credit Facility, Maximum Borrowing Capacity Marketable securities Debt Securities, Available-for-Sale, Excluding Accrued Interest, Current Royalty Pharma Agreement Interest Expense Interest Expense, Policy [Policy Text Block] Costs and operating expenses: Operating Expenses [Abstract] Debt instrument, royalty payment, ratio Debt Instrument, Royalty Payment, Ratio Debt Instrument, Royalty Payment, Ratio Statement [Line Items] Statement [Line Items] Summary of Charges and Spending Related to Restructuring Schedule of Restructuring Reserve by Type of Cost [Table Text Block] Rule 10b5-1 Arrangement Adopted Rule 10b5-1 Arrangement Adopted [Flag] Cash and cash equivalents Cash and Cash Equivalent 2020 Underwritten Public Offering Two Thousand Twenty Underwritten Public Offering [Member] Underwritten Public Offering [Member] Subsequent Event [Line Items] Subsequent Event [Line Items] Risk-free interest rate range, maximum Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum Common Stock Common Stock [Member] Vested (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period Net increase (decrease) in cash, cash equivalents and restricted cash Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation Professional legal and accounting fees Accrued Professional Fees, Current Statistical Measurement Statistical Measurement [Domain] Thereafter Lessee, Operating Lease, Liability, to be Paid, after Year Five Foreign currency and other adjustments Restructuring Reserve, Translation and Other Adjustment Gross Unrealized Losses Restricted Cash And Cash Equivalents Gross Unrealized Losses Restricted cash and cash equivalents gross unrealized losses. Leases [Abstract] Leases [Abstract] Accounts payable Increase (Decrease) in Accounts Payable Total interest and other income (expense) Interest Income (Expense), Nonoperating Gross Unrealized Losses Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax Trading Arrangements, by Individual Trading Arrangements, by Individual [Table] Warrants outstanding (in shares) Common stock outstanding warrants to purchase (in shares) Class of Warrant or Right, Outstanding Basic net loss per share (in dollars per share) Earnings Per Share, Basic Fair value measurements inter transfers between levels Fair Value Measurements Inter Transfers Between Levels Fair value measurements inter transfers between levels. Commercial paper Commercial Paper [Member] Liabilities: Liabilities, Fair Value Disclosure [Abstract] Common stock, shares reserved for future issuance (in shares) Common stock, shares reserved for future issuance (in shares) Common Stock, Capital Shares Reserved for Future Issuance New Jersey Lease And Foster City Lease New Jersey Lease And Foster City Lease [Member] New Jersey lease and Foster city lease member. Change in unrecognized tax benefit Effective Income Tax Rate Reconciliation, Tax Contingency, Percent Aggregate offering price of common stock Common Stock Aggregate Offering Price Represents the aggregate offering price for which the entity may elect to issue and sell shares of its common stock under the sales agreement. Total deferred tax assets Deferred Tax Assets, Gross Inventory Disclosure [Abstract] Inventory Disclosure [Abstract] Public Offering of Common Stock and Warrants Public Offering Of Common Stock And Warrants [Member] Public Offering of Common Stock and Warrants [Member] Weight Average Remaining Contractual Life (in years) Share Based Compensation Arrangement By Share Based Payment Award Options Weighted Average Remaining Contractual Life [Abstract] Weighted Average Remaining Contractual Life (In years) Proceeds from sale of future royalties Proceeds from Sale of Future Royalties Proceeds from sale of future royalties. Award Timing MNPI Disclosure Award Timing MNPI Disclosure [Text Block] Research and Development Expenses Research and Development Expense, Policy [Policy Text Block] Net operating loss not benefitted Effective Income Tax Rate Reconciliation, Net Operating Loss Not Benefitted, Amount Effective Income Tax Rate Reconciliation, Net Operating Loss Not Benefitted, Amount 2023 Sales Agreement At Market Issuance Two Thousand And Twenty Three Sales Agreement [Member] At market issuance two thousand and twenty three sales agreement. Total Share-based payment arrangement, expense Share-Based Payment Arrangement, Expense Current assets: Assets, Current [Abstract] Total liabilities and stockholders' equity Liabilities and Equity Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward] Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward] Concentration Risk Benchmark [Axis] Concentration Risk Benchmark [Axis] Increase in allowance for doubtful accounts Increase (Decrease) In Allowance For Doubtful Accounts Increase in allowance for doubtful accounts. Cash, cash equivalents and restricted cash at the beginning of the period Cash, cash equivalents and restricted cash at the end of the period Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation Other Deferred Tax Assets, Other Accounting Policies [Abstract] Accounting Policies [Abstract] Line of credit, maturity period Line of Credit Facility, Expiration Period Schedule of Undiscounted Future Non-cancellable Lease Payments Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block] Federal and state tax credits Deferred Tax Assets, Federal And State Credits Deferred tax assets federal and state credits. Concentration Risk Type [Domain] Concentration Risk Type [Domain] Total fair value of restricted stock that vested Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value Pay vs Performance Disclosure [Line Items] Operating lease, liability Total Operating Lease, Liability Stock-based compensation related to issuance of common stock and options in exchange for services (in shares) Stock Issued During Period, Shares, Issued for Services Manufacturing activities Accrued Manufacturing Activities Current Carrying value as of the balance sheet of obligations incurred through the date and payable for manufacturing related costs. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Non-cash interest expense on liabilities for sales of future royalties Noncash Interest Expense On Liabilities For Sales Of Future Royalties Non-cash interest expense on liabilities for sales of future royalties. Investment Holdings [Table] Investment Holdings [Table] Depreciation and amortization Depreciation, Depletion and Amortization, Nonproduction Net operating loss carryforwards, subject to expiration Operating Loss Carryforwards Subject To Expiration Operating loss carryforwards subject to expiration. Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Company Selected Measure Amount Company Selected Measure Amount 2023 Public Offering 2023 Underwritten Public Offering Two Thousand Twenty Three Underwritten Public Offering [Member] 2023 Underwritten Public Offering. 2028 Lessee, Operating Lease, Liability, to be Paid, Year Three Accrued bonuses Accrued Bonuses, Current Comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent Name Measure Name Schedule of Components of Income (Loss) Before Income Taxes Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block] Consultants Consultants [Member] Represents information pertaining to consultants. Total assets Assets Vested (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value Restricted Cash Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block] Income Taxes Income Tax, Policy [Policy Text Block] Cash flows from operating activities: Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract] ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Organization, Consolidation and Presentation of Financial Statements Disclosure and Significant Accounting Policies [Text Block] Other segment expenses Segment Reporting, Other Segment Item, Amount Concentration Risk Type [Axis] Concentration Risk Type [Axis] INVENTORY Inventory Disclosure [Text Block] Warrants exercised (in shares) Class of Warrant or Right, Exercised Class of Warrant or Right, Exercised Assets: Assets, Fair Value Disclosure [Abstract] Research and development Research and Development Expense (Excluding Acquired in Process Cost) Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Operating lease right-of-use asset Right-of-Use Asset Obtained in Exchange for Operating Lease Liability Schedule Of Available For Sale Securities [Line Items] Debt Securities, Available-for-Sale [Line Items] Level 2 Fair Value, Inputs, Level 2 [Member] Document Financial Statement Error Correction [Flag] Document Financial Statement Error Correction [Flag] State income tax, net of federal benefit Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount Insider Trading Policies and Procedures Not Adopted Insider Trading Policies and Procedures Not Adopted [Text Block] Royalties [Roll Forward] Royalties [Roll Forward] Royalties Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract] Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract] Gross Unrealized Gains Cash And Cash Equivalents Unrealized Gains Represents the gross unrealized gains for cash and cash equivalents. Schedule of Provision for (Benefit from) Income Taxes Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] Plan Name Plan Name [Axis] Property and Equipment Property, Plant and Equipment, Policy [Policy Text Block] PEO PEO [Member] Lease Contractual Term Lease Contractual Term [Domain] Interest income Investment Income, Interest Changes in assets and liabilities: Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract] Change in valuation allowance Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount Pre-Funded Warrants Pre Funded Warrants Purchase [Member] Pre-funded warrants purchase. Accumulated Deficit Retained Earnings [Member] Income Tax Authority Income Tax Jurisdiction [Axis] Schedule of Accrued Liabilities Schedule of Accrued Liabilities [Table Text Block] Income Statement [Abstract] Income Statement [Abstract] 12 Months or Longer Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer Purchases of marketable securities Payments to Acquire Marketable Securities Sale of Stock Sale of Stock [Domain] Deposits and other assets Deposits And Other Assets Noncurrent Carrying value of amounts transferred to third parties for security purposes that are expected to be returned or applied towards payment after one year or beyond the operating cycle, if longer; and amount of noncurrent assets classified as other. Product and Service [Domain] Product and Service [Domain] Marketable securities: Debt Securities, Available-for-Sale [Abstract] Customer Concentration Risk Customer Concentration Risk [Member] Severance Plan [Table] Severance Plan [Table] Severance plan. Sales returns and allowances Sales Returns And Allowance [Member] Sales returns and allowance. Restatement does not require Recovery Restatement Does Not Require Recovery [Text Block] Total Liabilities, Fair Value Disclosure 2024 Pre-funded Warrant Two Thousand Twenty Four Pre Funded Warrant [Member] Two thousand twenty four pre-funded warrant. City Area Code City Area Code Award Timing, How MNPI Considered Award Timing, How MNPI Considered [Text Block] Class of Warrant or Right [Line Items] Class of Warrant or Right [Line Items] Cash flows from investing activities: Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract] Pay vs Performance Disclosure Pay vs Performance Disclosure [Table] Supplier Supplier [Axis] Percentage of commitment amount to fund loan Percentage Of Commitment Amount To Fund Loan Percentage of commitment amount to fund loan. Selling, general and administrative Selling, General and Administrative Expenses [Member] Total lease costs Lease, Cost Cost of Sales Cost of Sales [Member] 2020 Stock Purchase Warrant Two Thousand Twenty Stock Purchase Warrants [Member] Two Thousand Twenty Stock Purchase Warrants [Member] Schedule of Components of Lease Costs Lease, Cost [Table Text Block] Period of base salary in connection with a non-change of control to be considered for severance payments Loss Contingency, Period Of Current Base Salary To Be Paid Under Severance Plan Non Change of Control Triggering Event Loss contingency period of current base salary to be paid under severance plan non change of control triggering event. Lease Contractual Term Lease Contractual Term [Axis] Unrecognized tax benefits Unrecognized Tax Benefits [Roll Forward] Auditor Name Auditor Name Stock-based compensation related to issuance of common stock and options in exchange for services Stock Issued During Period, Value, Issued for Services 2018 Plan Two Thousand And Eighteen Equity Incentive Plan [Member] 2018 equity incentive plan. Municipal securities (due in less than one year) Municipal Securities Due In Less Than One Year [Member] Municipal securities due in less than one year. Supplemental operating and investing activities: Supplemental Cash Flow Information [Abstract] Number of consecutive purchase periods in an offering period Share Based Compensation Arrangement By Share Based Payment Award Number Of Consecutive Purchase Periods In Each Offering Period Represents the number of consecutive purchase periods in an offering period in the purchase plan. Other Performance Measure, Amount Other Performance Measure, Amount Weighted Average Exercise Price Per Share Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] Marketable Securities Marketable Securities, Policy [Policy Text Block] Term Loans Term Loans [Member] Term loans. Fair Value Measurements Fair Value Measurement, Policy [Policy Text Block] Amount Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract] Tranche B Tranche B [Member] Tranche B [Member] Additional paid-in capital Additional Paid in Capital, Common Stock Net cash provided by (used in) investing activities Cash Provided by (Used in) Investing Activity, Including Discontinued Operation Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table [Member] Liability related to sale of future royalties Liability Related To Sale Of Future Royalties, Current Liability Related To Sale Of Future Royalties, Current Interest paid Interest Paid, Excluding Capitalized Interest, Operating Activity Total gross-to-net adjustments Total Gross To Net Adjustments [Member] Total gross to net adjustments. Document Fiscal Year Focus Document Fiscal Year Focus Basis of Presentation Basis of Accounting, Policy [Policy Text Block] STOCKHOLDERS' EQUITY Shareholders' Equity and Share-Based Payments [Text Block] Operating leases, right-of-use assets Operating lease, right-of-use asset Operating Lease, Right-of-Use Asset Effective tax rate Effective Income Tax Rate Reconciliation, Percent Decrease related to prior year tax positions Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions Operating lease costs Operating Lease, Cost Accrued other Other Employee-related Liabilities, Current Plan Name Plan Name [Domain] Tranche C Tranche C [Member] Tranche C [Member] Share-based payment arrangement, nonvested award, cost not yet recognized, period for recognition Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Stock options exercised (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period Less: valuation allowance Deferred Tax Assets, Valuation Allowance Equity [Abstract] Maximum duration of offering period Share Based Compensation Arrangement By Share Based Payment Award Maximum Duration Of Offering Period Represents the maximum duration of the offering period under the employee stock purchase plan. 2011 Plan Incentive Award Plan2011 [Member] Represents information pertaining to the 2011 Incentive Award Plan. SEGMENT REPORTING Segment Reporting Disclosure [Text Block] Fair Value on a Recurring Basis Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Increase (Decrease) in Stockholders' Equity Increase (Decrease) in Stockholders' Equity [Roll Forward] Gross Unrealized Losses Debt Securities, Available-for-Sale, Unrealized Loss Position, Accumulated Loss [Abstract] Employee stock purchase plan (in shares) Share-Based Compensation Arrangement By Share-Based Payment Award, Employee Stock Purchase Plans Share-Based Compensation Arrangement By Share-Based Payment Award, Employee Stock Purchase Plans Stock Based compensation - 162(m) Effective Income Tax Rate Reconciliation, Share-Based Payment Arrangement Limit, Amount Effective Income Tax Rate Reconciliation, Share-Based Payment Arrangement Limit, Amount Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering, net of issuance costs Public Offering Stock Issued During Period Value New Issue Public offering stock issued during period value new issues. Compensation Actually Paid vs. Total Shareholder Return Compensation Actually Paid vs. Total Shareholder Return [Text Block] Chargebacks Chargebacks [Member] Chargeback and distributor service fees. Accrued 401K match Liability, Pension and Other Postretirement and Postemployment Benefits, Current Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table] Fair Value, Recurring and Nonrecurring [Table] Leases Lessee, Leases [Policy Text Block] Selling, general and administrative Commercial expenses Selling, General and Administrative Expense Restricted cash Amortized Cost Restricted Cash and Cash Equivalent, Current Aggregate common stock offering price Sale Of Stock, Aggregate Offering Price Sale Of Stock, Aggregate Offering Price Accounts Receivable Accounts Receivable [Policy Text Block] Foreign rate difference Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Amount Arrangement Duration Trading Arrangement Duration Net operating loss not benefitted Effective Income Tax Rate Reconciliation, Net Operating Loss Not Benefitted, Percent Effective income tax Rate reconciliation net operating loss not benefitted. Expected volatility range, maximum Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum Purchase obligation, written notice term Purchase Obligation, Written Notice Term Purchase Obligation, Written Notice Term Segments [Axis] Segments [Axis] Subsequent Director Option Subsequent Director Option [Member] Represents information pertaining to the stock options to be granted by the entity subsequent to the grant upon first appointment to the Board of Directors. Local Phone Number Local Phone Number Additional 402(v) Disclosure Additional 402(v) Disclosure [Text Block] Collaborative Arrangement and Arrangement Other than Collaborative Collaborative Arrangement and Arrangement Other than Collaborative [Domain] Thereafter Long-Term Debt, Maturity, after Year Five ASSETS Assets [Abstract] Net unrealized loss on marketable securities OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment, before Tax Credit Facility Credit Facility [Axis] Underlying Security Market Price Change Underlying Security Market Price Change, Percent Debt Instrument Debt Instrument [Axis] Forfeited (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value FAIR VALUE MEASUREMENTS Fair Value Disclosures [Text Block] Loss on extinguishment of debt Loss of extinguishment of debt Gain (Loss) on Extinguishment of Debt Credit Facility Credit Facility [Domain] Stockholders' equity: Equity, Attributable to Parent [Abstract] Audit Information [Abstract] Audit Information Commission for agent on sales Sale Of Stock, Aggregate Commission Percentage Sale Of Stock, Aggregate Commission Percentage Noncurrent operating lease liabilities Operating Lease, Liability, Noncurrent Entity Voluntary Filers Entity Voluntary Filers Non-cash interest expense recognized Royalty Expense Pharmakon Loan Agreement Pharmakon Loan Agreement [Member] Pharmakon loan agreement. Property, Plant and Equipment [Abstract] Property, Plant and Equipment [Abstract] Entity Registrant Name Entity Registrant Name Operating lease, percentage of discount rate Lessee, Operating Lease, Discount Rate Stock Price or TSR Estimation Method Stock Price or TSR Estimation Method [Text Block] Municipal securities Municipal Bonds [Member] Customer One Customer One [Member] Customer One Issuance costs Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs Total Assets, Fair Value Disclosure Schedule of Common Stock Reserved for Future Issuance Schedule Of Common Stock Reserved For Future Issuance [Table Text Block] Tabular disclosure of common stock reserved for future issuance, which may include but is not limited to outstanding options and outstanding warrants. Number of operating segment Number of Operating Segments Accretion and amortization on investments, net Accretion (Amortization) of Discounts and Premiums, Investments Number of offering periods in which an employee can participate at a time Share Based Compensation Arrangement By Share Based Payment Award Maximum Number Of Offering Periods In Which Employee May Participate At One Time Represents the number of offering periods in which an employee can participate at a time in the purchase plan. Granted (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Collaborative Arrangement and Arrangement Other than Collaborative Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Restatement Determination Date: Restatement Determination Date [Axis] Issuances of common stock under equity plans Shares Issued, Value, Share-Based Payment Arrangement, after Forfeiture Accounts Receivable Accounts Receivable [Member] Segment Reporting, Revenue Reconciling Item [Line Items] Segment Reporting, Revenue Reconciling Item [Line Items] Name Trading Arrangement, Individual Name Reconciliation of Revenue from Segments to Consolidated [Table] Reconciliation of Revenue from Segments to Consolidated [Table] Long-term manufacturing commitments, amount Long-Term Purchase Commitment, Amount Scenario One Scenario One [Member] Scenario one. Statement of Comprehensive Income [Abstract] Statement of Comprehensive Income [Abstract] Cost of goods sold Operating Costs and Expenses Name Awards Close in Time to MNPI Disclosures, Individual Name Payments Payments for Restructuring Unvested, beginning balance (in dollars per share) Unvested, ending balance (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Aggregate Erroneous Compensation Not Yet Determined Aggregate Erroneous Compensation Not Yet Determined [Text Block] Debt Instrument, Scenario [Axis] Debt Instrument, Scenario [Axis] Debt Instrument, Scenario Issuance of common stock, pre-funded warrant and warrants to purchase common stock in public offering, net of issuance costs (in shares) Public Offering Stock Issued During Period Shares New Issues Public offering stock issued during period shares new issues. ICFR Auditor Attestation Flag ICFR Auditor Attestation Flag Amortized Cost Cash Equivalents, at Carrying Value Stock-based compensation for equity-based awards to employees and directors APIC, Share-Based Payment Arrangement, Increase for Cost Recognition Service based options Service Based Options [Member] Service Based Options Stock Based compensation - 162(m) Effective Income Tax Rate Reconciliation, Share-Based Payment Arrangement Limit, Percent Effective Income Tax Rate Reconciliation, Share-Based Payment Arrangement Limit, Percent Stock options fully vested and expected to vest at the end of the period Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value Auditor Firm ID Auditor Firm ID Segments [Domain] Segments [Domain] 2018 Inducement Award Plan Two Thousand And Eighteen Inducement Award Plan [Member] Two thousand and eighteen inducement award plan. Income Statement Location Statement of Income Location, Balance [Axis] Foreign Income (Loss) from Continuing Operations before Income Taxes, Foreign Fair Value Hierarchy and NAV Fair Value Hierarchy and NAV [Domain] Inventory Increase (Decrease) in Inventories Outstanding stock options and units (in shares) Share-Based Compensation Arrangement By Share-Based Payment Award, Options And Non Option Equity Instruments, Outstanding, Number Share-Based Compensation Arrangement By Share-Based Payment Award, Options And Non Option Equity Instruments, Outstanding, Number Amortization of debt issuance costs/debt discount Amortization of Debt Issuance Costs and Discounts Warrants to purchase common stock (in shares) Class of Warrant or Right, Number of Securities Called by Warrants or Rights U.S. Treasury securities (due in less than one year) U S Treasury Securities Due In Less Than One Year [Member] US Treasury Securities Due In less than one Year Member. Less accumulated depreciation and amortization Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Net Loss Per Share Earnings Per Share, Policy [Policy Text Block] Preferred stock, $0.001 par value; 3,000,000 shares authorized; no shares issued and outstanding at December 31, 2025 and 2024 Preferred Stock, Value, Issued All Executive Categories All Executive Categories [Member] Total Share-Based Payment Arrangement, Expensed and Capitalized, Amount Schedule of Significant Components of Deferred Tax Assets Schedule of Deferred Tax Assets and Liabilities [Table Text Block] Finished goods Inventory, Finished Goods, Net of Reserves Common stock, $0.001 par value; 1,350,000,000 shares authorized; 639,856,222 and 606,387,666 shares issued and outstanding at December 31, 2025 and 2024, respectively Common Stock, Value, Issued Title and Position [Axis] Title and Position [Axis] Commitments and contingencies Commitments and Contingencies Minimum exercise price as a percentage of fair market value for employees having more than 10 % outstanding common stock Share Based Compensation Arrangement By Share Based Payment Award Minimum Exercise Price Of Options Granted To Employees With More Than10 Percentage Of Common Stock Share based compensation arrangement by share based payment award minimum exercise price of options granted to employees with more than 10 percentage of common stock. Total net deferred tax assets Deferred Tax Assets, Net PEO Actually Paid Compensation Amount PEO Actually Paid Compensation Amount Customer Two Customer Two [Member] Customer Two Stock options cancelled/forfeited/expired (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period Duration of the purchase period Share Based Compensation Arrangement By Share Based Payment Award Duration Of Purchase Period Represents the duration of the purchase period under the employee stock purchase plan. OTHER CONSOLIDATED FINANCIAL STATEMENT DETAILS Supplemental Balance Sheet Disclosures [Text Block] Directors Market Value Stock Purchase Plan Directors Market Value Stock Purchase Plan [Member] Directors’ market value stock purchase plan. Revenue from Contract with Customer [Abstract] Revenue from Contract with Customer [Abstract] Schedule of Reconciliation of the Beginning and Ending Amounts of Unrecognized Tax Benefits Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block] All Individuals All Individuals [Member] Fair Value Disclosures [Abstract] Fair Value Disclosures [Abstract] Noncurrent liability related to sale of future royalties Liability Related To Sale Of Future Royalties, Noncurrent Liability Related To Sale Of Future Royalties, Noncurrent Name Forgone Recovery, Individual Name Expiration term of stock options from date of grant Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested [Member] Proceeds from issuances of common stock from equity plans Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Including Option Exercised Schedule of Activity Within Liability Related to Sale of Future Royalties Schedule Of Activity Within Liability Related To Sale Of Future Royalties [Table Text Block] Schedule of activity within liability related to sale of future royalties. Percentage applied to common stock market value in calculating purchase price under purchase plan Share-Based Compensation Arrangement by Share-Based Payment Award, Purchase Price of Common Stock, Percent Erroneous Compensation Analysis Erroneous Compensation Analysis [Text Block] Lessee Lease Description [Line Items] Lessee, Lease, Description [Line Items] Other comprehensive income (loss) OCI, Debt Securities, Available-for-Sale, Gain (Loss), before Adjustment, after Tax Rule 10b5-1 Arrangement Terminated Rule 10b5-1 Arrangement Terminated [Flag] Maximum percentage of annual salary that can be withheld Share Based Compensation Arrangement By Share Based Payment Award Maximum Percentage Of Annual Salary That Can Be Withheld Represents the maximum percentage of annual salary that an employee can choose to have withheld to purchase common stock under the purchase plan. Erroneously Awarded Compensation Recovery Erroneously Awarded Compensation Recovery [Table] Concentration Risk Benchmark [Domain] Concentration Risk Benchmark [Domain] Title of 12(b) Security Title of 12(b) Security Lessee Lease Description [Table] Lessee, Lease, Description [Table] Loss contingency, number of plaintiffs Loss Contingency, Number of Plaintiffs Earnings Per Share, Basic, by Common Class, Including Two Class Method [Line Items] Earnings Per Share, Basic, by Common Class, Including Two Class Method [Line Items] Earnings Per Share [Abstract] 2030 Lessee, Operating Lease, Liability, to be Paid, Year Five Tax credit carryforwards Tax Credit Carryforward, Amount Gross Unrealized Gains Restricted Cash And Cash Equivalents, Gross Unrealized Gains Restricted Cash And Cash Equivalents, Gross Unrealized Gains Stock options exercised (in dollars per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Award Timing Disclosures [Line Items] Operating Loss Carryforwards [Line Items] Operating Loss Carryforwards [Line Items] Schedule of Inventory Schedule of Inventory, Current [Table Text Block] Operating lease term, option to extend additional period Lessee, Operating Lease, Renewal Term Net loss Net loss Net Income (Loss) Attributable to Parent Subsequent Event [Table] Subsequent Event [Table] Employees Above The Vice President Level Employees Above The Vice President Level [Member] Employees above the vice president level. Other Other Accrued Liabilities, Current Subscription receivables (in shares) Stock Issued During Period, Shares, Subscription Receivables Stock Issued During Period, Shares, Subscription Receivables Reconciliation of the Federal Statutory Tax Rate to the Effective Income Tax Rate from Continuing Operations Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] Vesting period of stock options Vesting period of awards Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period Other Effective Income Tax Rate Reconciliation, Other Adjustments, Percent Preferred stock, authorized (in shares) Preferred Stock, Shares Authorized Adoption Date Trading Arrangement Adoption Date Public offering price of common stock (in dollars per share) Shares Issued, Price Per Share Operating lease, initial term Lessee, Operating Lease, Term of Contract Customer [Axis] Customer [Axis] Selling, General and Administrative Expense Selling, General and Administrative Expenses, Policy [Policy Text Block] Loss from operations Operating Income (Loss) Accumulated deficit Retained Earnings (Accumulated Deficit) Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested [Member] Subsequent Event Type Subsequent Event Type [Domain] Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table [Member] Payables and Accruals [Abstract] Payables and Accruals [Abstract] Other income (expense), net Other Nonoperating Income (Expense) Statement [Table] Statement [Table] 2020 Public Offering of Common Stock and Warrants Two Thousand Twenty Public Offering Of Common Stock And Warrants [Member] 2020 Public Offering of Common Stock and Warrants. Cash flows from financing activities: Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract] CRO and clinical trial costs Accrued Clinical Research Organizations And Clinical Trial Costs Current Carrying value as of the balance sheet date of obligations incurred through that date and payable for clinical related costs. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). New Jersey Office Space Lease New Jersey Office Space Lease [Member] New jersey office space lease. All Adjustments to Compensation All Adjustments to Compensation [Member] Amendment Flag Amendment Flag Public offering price (in dollars per share) Sale of Stock, Price Per Share Floor rate Debt Instrument Floor Rate Debt instrument floor rate. Operating lease liabilities Deferred Tax Assets, Operating Lease Liabilities Deferred tax assets operating lease liabilities. Termination Date Trading Arrangement Termination Date Insider Trading Policies and Procedures Adopted Insider Trading Policies and Procedures Adopted [Flag] Public Offering [Line Items] Public Offering [Line Items] Public offering. Debt Instrument, Variable Interest Rate, Type [Extensible Enumeration] Debt Instrument, Variable Interest Rate, Type [Extensible Enumeration] U.S. Treasury securities (due in one to two years) U S Treasury Securities Due In One To Two Years [Member] US Treasury securities due in one to two years member. Raw materials Inventory, Raw Materials, Net of Reserves Operating lease, weighted average discount rate, percent Operating Lease, Weighted Average Discount Rate, Percent Schedule of Stock Option Activity Share-Based Payment Arrangement, Option, Activity [Table Text Block] Schedule of Financial Instruments Measured at Fair Value on Recurring Basis Fair Value, Assets Measured on Recurring Basis [Table Text Block] Weighted average common shares outstanding, basic (in shares) Weighted Average Number of Shares Outstanding, Basic Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table] Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table] Corporate notes (due in less than one year) Corporate Note Securities Due In Less Than One Year [Member] This category includes information about short-term debt securities that are issued by either a domestic or foreign corporate business entity with a date certain promise of repayment and a return to the holder for the time value of money (for example, variable or fixed interest), due in less than one year. CONSOLIDATED STATEMENTS OF CASH FLOWS DATA Cash Flow, Supplemental Disclosures [Text Block] Unrecognized tax benefits, if recognized would impact effective tax rate Unrecognized Tax Benefits that Would Impact Effective Tax Rate Stock options exercisable at the end of the period (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number Period within which employee resigns following a change of control due to material change in terms of employment Loss Contingency, Triggering Event Period Following Change Of Control Within Which Employee Resigns Due To Material Change In Terms Of Employment Represents the period within which employee resigns following a change of control due to material change in terms of employment and to be considered as triggering event for severance payments. Subsequent Events [Abstract] Subsequent Events [Abstract] Segment Reporting [Abstract] Segment Reporting [Abstract] Supplier Supplier [Domain] Debt Disclosure [Abstract] Debt Disclosure [Abstract] Stock-based compensation for services by non-employees Issuance of Stock and Warrants for Services or Claims At Market Issuance Sales Agreements [Line Items] At Market Issuance Sales Agreements [Line Items] At Market Issuance Sales Agreements. Restructuring and Related Activities [Abstract] Forgone Recovery due to Expense of Enforcement, Amount Forgone Recovery due to Expense of Enforcement, Amount Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Common stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share Stock options granted (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross Use of Estimates Use of Estimates, Policy [Policy Text Block] Schedule of Assumptions Used to Estimate the Fair Value of Employee Stock Purchases Under the Purchase Plan Schedule of Share-Based Payment Award, Employee Stock Purchase Plan, Valuation Assumptions [Table Text Block] Restructuring Charges Costs Associated with Exit or Disposal Activity or Restructuring [Policy Text Block] Duration of the new offering period Share Based Compensation Arrangement By Share Based Payment Award Duration Of New Offering Period Represents the duration of new offering period in a case where the fair market value of common stock on the purchase date is less than the fair market value at the beginning of the offering period. SUBSEQUENT EVENTS Subsequent Events [Text Block] Deposit and other assets Increase (Decrease) in Deposit Assets Foreign currency translation adjustments Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax Insider Trading Arrangements [Line Items] Stock options cancelled/forfeited/expired (in dollars per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price Shares Share-Based Compensation Arrangement by Share-Based Payment Award, Non-Option Equity Instruments, Outstanding [Roll Forward] Total liabilities Liabilities Antidilutive Securities, Name Antidilutive Securities, Name [Domain] Cash and Cash Equivalents [Axis] Cash and Cash Equivalents [Axis] Pension Adjustments Prior Service Cost Pension Adjustments Prior Service Cost [Member] Increase related to current year tax positions Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions Material Terms of Trading Arrangement Material Terms of Trading Arrangement [Text Block] Counterparty Name Counterparty Name [Axis] Schedule of Restricted Stock Units Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block] Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Non-NEOs Non-NEOs [Member] Secured Overnight Financing Rate (SOFR) [Member]